Research Description

We use longitudinal functional imaging, in vivo electrophysiology, as well as a large toolbox of techniques that allow us to monitor and perturb various neuronal functions. Using these methodologies, we answer fundamental questions about how plasticity within neuronal and dendritic compartments supports constant learning. Finally, by understanding these processes at a mechanistic level, we aim to facilitate treatment and therapies for neurological conditions such as aging and Alzheimer's disease when normal cognitive function goes awry.

Our work is guided by the understanding that the brain is more than neurons and neurons are more than somas. Our lab seeks to understand encoding of memories, their transformation and organization at subcellular, cellular, micro-circuit and circuit level. To do this, we use a variety of imaging techniques to monitor neural activity. Using techniques such as activity-dependent tagging, optogenetics, chemogenetics amongst others we then manipulate neuronal function to seek to establish causality.