Publications (co-)authored by James Cowan with students in the Biophysics program

[1] 

Stephen A Pearson, Christine Wachnowsky, and J A Cowan
"Defining the mechanism of the mitochondrial Atm1p 2Fe-2S cluster exporter."
Metallomics 12, 902-915 (2020).

[2] 

Nathaniel A Wesley, Christine Wachnowsky, Insiya Fidai, and J A Cowan
"Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 MMDS1: impact of a disease-causing Gly189Arg substitution on NFU1."
FEBS J. 284, 3838-3848 (2017).

[3] 

Nathaniel A Wesley, Christine Wachnowsky, Insiya Fidai, and J A Cowan
"Analysis of NFU-1 metallocofactor binding-site substitutions-impacts on iron-sulfur cluster coordination and protein structure and function."
FEBS J. 284, 3817-3837 (2017).

[4] 

Martin James Ross, Insiya Fidai, and James A Cowan
"Analysis of Structure-Activity Relationships Based on the Hepatitis C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK⋅Cu Complex."
Chembiochem 18, 1743-1754 (2017).

[5] 

Christine Wachnowsky, Nathaniel A Wesley, Insiya Fidai, and J A Cowan
"Understanding the Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 1 MMDS1-Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway."
J. Mol. Biol. 429, 790-807 (2017).

[6] 

Insiya Fidai, Christine Wachnowsky, and J A Cowan
"Mapping cellular Fe-S cluster uptake and exchange reactions - divergent pathways for iron-sulfur cluster delivery to human ferredoxins."
Metallomics 8, 1283-1293 (2016).

[7] 

Christine Wachnowsky, Insiya Fidai, and James A Cowan
"Cytosolic iron-sulfur cluster transfer-a proposed kinetic pathway for reconstitution of glutaredoxin 3."
FEBS Lett. 590, 4531-4540 (2016).

[8] 

Insiya Fidai, Christine Wachnowsky, and J A Cowan
"Glutathione-complexed 2Fe-2S clusters function in Fe-S cluster storage and trafficking."
J. Biol. Inorg. Chem. 21, 887-901 (2016).

[9] 

Christine Wachnowsky, Insiya Fidai, and J A Cowan
"Iron-sulfur cluster exchange reactions mediated by the human Nfu protein."
J. Biol. Inorg. Chem. 21, 825-36 (2016).

[10] 

Jingwei Li, Stephen A Pearson, Kevin D Fenk, and J A Cowan
"Glutathione-coordinated 2Fe-2S cluster is stabilized by intramolecular salt bridges."
J. Biol. Inorg. Chem. 20, 1221-7 (2015).

[11] 

Insiya Fidai, Lalintip Hocharoen, Seth Bradford, Christine Wachnowsky, and J A Cowan
"Inactivation of sortase A mediated by metal ATCUN complexes."
J. Biol. Inorg. Chem. 19, 1327-39 (2014).

[12] 

Seth S Bradford, Martin James Ross, Insiya Fidai, and James A Cowan
"Insight into the Recognition, Binding, and Reactivity of Catalytic Metallodrugs Targeting Stem Loop IIb of Hepatitis C IRES RNA."
ChemMedChem 9, 1275-85 (2014).

[13] 

Sheref S Mansy, Yong Xiong, Craig Hemann, Russ Hille, M Sundaralingam, and J A Cowan
"Crystal structure and stability studies of C77S HiPIP a serine ligated 4Fe-4S cluster."
Biochemistry 41, 1195-201 (2002).

[14] 

M W Foster, S Bian, K K Surerus, and J A Cowan
"Elucidation of a 4Fe-4S cluster degradation pathway rapid kinetic studies of the degradation of Chromatium vinosum HiPIP."
J. Biol. Inorg. Chem. 6, 266-74 (2001).

[15] 

S Bian, C F Hemann, R Hille, and J A Cowan
"Characterization of an autoreduction pathway for the Fe4S43 cluster of mutant Chromatium vinosum high-potential iron proteins. Site-directed mutagenesis studies to probe the role of phenylalanine 66 in defining the stability of the Fe4S4 center provide evidence for oxidative degradation via a Fe3S4 cluster."
Biochemistry 35, 14544-52 (1996).

[16] 

A Soriano, D Li, S Bian, A Agarwal, and J A Cowan
"Factors influencing redox thermodynamics and electron self-exchange for the Fe4S4 cluster in Chromatium vinosum high potential iron protein the role of core aromatic residues in defining cluster redox chemistry."
Biochemistry 35, 12479-86 (1996).

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