Research Description

We are quantitatively investigating the mechanisms by which our genome is expressed and repaired. Our approach is to apply a cross-disciplinary techniques that combines biochemical, biophysical and single molecule techniques, which includes: restriction enzyme studies, cyclization experiments, nucleosome mapping, steady state Fluorescence Resonance Energy Transfer measurements (FRET), stopped flow FRET, fluorescence correlation spectroscopy, single molecule force and twist measurements with magnetic tweezers, Atomic Force Microscopy (AFM) measurements and single molecule FRET measurements.