Thomas Hund

Research Description:

The overall goal of the Hund lab is to discover novel pathways for regulation of cardiac excitability and function that will suggest new therapeutic strategies for human patients suffering from common forms of cardiovascular disease. In this vein, a major interest of the lab has been how local signaling domains for the multifunctional calmodulin kinase II (CaMKII) are organized in cardiac myocytes and fibroblasts motivated by the strong link between dysregulation in CaMKII signaling, arrhythmias and disease. This effort has resulted in a number of important findings providing new insight into the molecular mechanisms for regulation of cardiac function with relevance to common forms of human cardiovascular disease, including myocardial infarction, heart failure and cardiometabolic disease. In general, the lab employs a highly interdisciplinary approach combining state-of-the-art computational and experimental techniques that has generated novel computational models and tools to study cardiac electrophysiology and arrhythmia that are routinely used by labs around the world.